abstract：OBJECTIVE:To identify clinical and demographic characteristics associated with the absence of opioid usage on the day before discharge among patients undergoing open gynecologic surgery within an enhanced recovery after surgery (ERAS) program. METHODS:This was a single institution retrospective cohort study including ...

journal_title：Gynecologic oncology

authors： Hillman RT,Sanchez-Migallon A,Meyer LA,Iniesta MD,Cain KE,Siverand AM,Veum SPL,Suki TS,Lasala JD,Ramirez PT

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:To test whether platelets could increase invasion potential and initiate EMT in ovarian cancer cells via a TGF-β signaling pathway. METHODS:Blood samples were collected in 69 patients with ovarian cancer, 16 patients with benign ovarian tumor and 64 healthy donors. SK-OV-3 and OVCAR-3 ovarian cancer cells we...

journal_title：Gynecologic oncology

authors： Guo Y,Cui W,Pei Y,Xu D

更新日期：2019-06-01 00:00:00

abstract：:Sentinel node mapping is increasingly being utilized for endometrial cancer staging. However, only limited evidence supporting the adoption of sentinel node mapping instead of conventional lymphadenectomy is still available. Here, we aimed to review the current evidence comparing sentinel node mapping and lymphadenect...

journal_title：Gynecologic oncology

authors： Bogani G,Murgia F,Ditto A,Raspagliesi F

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:The PI3K/AKT/mTOR pathway is frequently overactivated in endometrial cancer (EC). We assessed the efficacy of ABTL0812, a novel first-in-class molecule presenting a unique mechanism of action inhibiting this pathway. METHODS:We investigated the effects of ABTL0812 on proliferation, cell death and modulation...

journal_title：Gynecologic oncology

authors： Felip I,Moiola CP,Megino-Luque C,Lopez-Gil C,Cabrera S,Solé-Sánchez S,Muñoz-Guardiola P,Megias-Roda E,Pérez-Montoyo H,Alfon J,Yeste-Velasco M,Santacana M,Dolcet X,Reques A,Oaknin A,Rodríguez-Freixinos V,Lizcano JM,Domèn

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:To compare the incidence of postoperative complications and opioid pain medication usage in gynecologic oncology patients who did and did not receive an epidural prior to undergoing exploratory laparotomy. METHODS:Retrospective cohort study of all patients undergoing exploratory laparotomy with the gynecolog...

journal_title：Gynecologic oncology

authors： Huepenbecker SP,Cusworth SE,Kuroki LM,Lu P,Samen CDK,Woolfolk C,Deterding R,Wan L,Helsten DL,Bottros M,Mutch DG,Powell MA,Massad LS,Thaker PH

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Mucinous borderline ovarian tumor (mucinous-BOT) and invasive well-differentiated mucinous ovarian cancer (mucinous-OC) are often histopathologically misclassified. The objective of this study was to examine differences in clinico-pathological characteristics and outcomes of these two entities. METHODS:This ...

journal_title：Gynecologic oncology

authors： Matsuo K,Machida H,Mandelbaum RS,Grubbs BH,Roman LD,Sood AK,Gershenson DM

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:The ability to minimize residual disease during primary cytoreductive surgery is the strongest predictor for improved overall survival in advanced ovarian cancer. But while the probability to achieve a macroscopic complete resection increases if surgery is preceded by neoadjuvant chemotherapy (NACT), survi...

journal_title：Gynecologic oncology

authors： Timmermans M,van der Hel O,Sonke GS,Van de Vijver KK,van der Aa MA,Kruitwagen RF

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Aberrant expression of HER2/neu and PIK3CA gene products secondary to amplification/mutations are common in high-grade-serous-endometrial (USC) and ovarian-cancers (HGSOC). Because scant information is currently available in the literature on the potential negative effect of PIK3CA mutations on the activity o...

journal_title：Gynecologic oncology

authors： Bonazzoli E,Cocco E,Lopez S,Bellone S,Zammataro L,Bianchi A,Manzano A,Yadav G,Manara P,Perrone E,Haines K,Espinal M,Dugan K,Menderes G,Altwerger G,Han C,Zeybek B,Litkouhi B,Ratner E,Silasi DA,Huang GS,Azodi M,

更新日期：2019-04-01 00:00:00

abstract：:One of the most prevalent potential therapeutic targets for women with endometrioid endometrial cancer (EC) is the estrogen receptor (ER)/progesterone receptor (PR) pathway. Despite a high proportion of endometrioid ECs being ER and/or PR positive, endocrine therapy is only effective in a minority of women with EC and...

journal_title：Gynecologic oncology

authors： Jerzak KJ,Duska L,MacKay HJ

更新日期：2019-04-01 00:00:00

abstract：:An estimated 2-5% of endometrial cancers and 15-20% of high-grade, non-mucinous epithelial ovarian cancers have an underlying hereditary cause. Appropriate risk assessment, genetic counseling, and germline genetic testing for cancer predisposition genes in both gynecologic cancer patients and their at-risk relatives i...

journal_title：Gynecologic oncology

authors： Hinchcliff EM,Bednar EM,Lu KH,Rauh-Hain JA

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix. As shown in the original Japanese group description, in recent studies, GAS represents a more aggressive disease than the usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features of...

journal_title：Gynecologic oncology

authors： Nishio S,Mikami Y,Tokunaga H,Yaegashi N,Satoh T,Saito M,Okamoto A,Kasamatsu T,Miyamoto T,Shiozawa T,Yoshioka Y,Mandai M,Kojima A,Takehara K,Kaneki E,Kobayashi H,Kaku T,Ushijima K,Kamura T

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:Implicit prejudice and stereotyping may exist in health care providers automatically without their awareness. These biases can correlate with outcomes that are consequential for the patient. This study examined gynecologic oncology care providers' implicit prejudice and stereotyping toward cervical cancer. M...

journal_title：Gynecologic oncology

authors： Liang J,Wolsiefer K,Zestcott CA,Chase D,Stone J

更新日期：2019-04-01 00:00:00

abstract：:Clinical research in gynecologic oncology has seen a proliferation of studies that investigate the effectiveness of treatments using existing data sources such as cancer registries, electronic health records, and insurance claims. These observational studies are often feasible when randomized trial may not be, and may...

journal_title：Gynecologic oncology

authors： Moss HA,Melamed A,Wright JD

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Australia's HPV vaccination and HPV-based cervical screening programs are changing the landscape in cervical cancer prevention. We aim to identify areas which can make the biggest further impact on cervical cancer burden. This protocol describes the first stage of a program of work called Pathways-Cervix that...

journal_title：Gynecologic oncology

authors： Velentzis LS,Smith MA,Simms KT,Lew JB,Hall M,Hughes S,Yuill S,Killen J,Keane A,Butler K,Darlington-Brown J,Hui H,Brotherton JML,Skinner R,Brand A,Roeske L,Heley S,Carter J,Bateson D,Frazer I,Garland SM,Guy R,H

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:To evaluate safety, tolerability, and antitumor activity of pembrolizumab monotherapy in patients with programmed death ligand 1 (PD-L1)-expressing advanced ovarian cancer enrolled in the multicohort, phase Ib KEYNOTE-028 trial. METHODS:Key inclusion criteria were age ≥18 years; advanced ovarian epithelial, ...

journal_title：Gynecologic oncology

authors： Varga A,Piha-Paul S,Ott PA,Mehnert JM,Berton-Rigaud D,Morosky A,Yang P,Ruman J,Matei D

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy, feasibility and safety of image-based, inversely and adaptively planned high-dose rate interstitial brachytherapy (HDR-ISBT) to treat advanced primary or recurrent gynecologic malignancy in a single implant, three-consecutive-day regimen. METHODS:Clinical demographics and outcome da...

journal_title：Gynecologic oncology

authors： Hanania AN,Myers P,Yoder AK,Bulut A,Henry Yu Z,Eraj S,Bowers J,Bonnen MD,Echeverria A,Hall TR,Anderson ML,Ludwig M

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Mesenchymal (MES) subtype of high-grade serous ovarian cancer (HGSOC) is associated with worse outcomes including survival and resectability compared with other molecular subtypes. Molecular subtypes have historically been derived from 'tumor', consisting of both cancer and stromal cells. We sought to determi...

journal_title：Gynecologic oncology

authors： Zhang Q,Wang C,Cliby WA

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To determine the incidence and risk factors for venous thromboembolism (VTE) within six months after primary debulking surgery (PDS) for epithelial ovarian cancer (EOC). METHODS:In a historical cohort, we estimated the cumulative incidence of clinically diagnosed VTE within 6 months among consecutive women w...

journal_title：Gynecologic oncology

authors： Wagner BE,Langstraat CL,McGree ME,Weaver AL,Sarangi S,Mokri B,Dowdy SC,Cliby WA,Kumar A,Bakkum-Gamez JN

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the contribution of molecular subtype to 30-day postoperative complications and 90-day mortality after primary debulking surgery (PDS) in advanced stage high-grade serous ovarian cancer (HGSOC). METHODS:Patients with stages III-IV HGSOC undergoing PDS from 1994 to 2011 with available molecular su...

journal_title：Gynecologic oncology

authors： Torres D,Kumar A,Bakkum-Gamez JN,Weaver AL,McGree ME,Wang C,Langstraat CL,Cliby WA

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVES:We sought to determine a baseline and five-year follow up sexual function score in women undergoing hysterectomy for endometrial cancer. METHODS:A cross-section of endometrial cancer patients receiving care from 2006 to 2010 was identified. Patients were surveyed during academic year 2011 using the Pelvic O...

journal_title：Gynecologic oncology

authors： Buckingham L,Haggerty A,Graul A,Morgan M,Burger R,Ko E,Andy U,Giuntoli R

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Nuclear lamina plays important roles in nuclear shape and mechanical stability. Many studies demonstrated that defects of lamin-A were associated with several diseases, but little research was found on its potential roles in ovarian cancer. METHODS:GEPIA and GEO database were used to analyze lamin-A in ovari...

journal_title：Gynecologic oncology

authors： Wang Y,Jiang J,He L,Gong G,Wu X

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Pelvic exenteration (PE) is an extensive surgery associated with high rates of postoperative morbidity and mortality. The absence of well-defined preoperative selection criteria to identify patients eligible for PE prompted the assessment of pre-operative predictors of 30-day major surgical complications. ME...

journal_title：Gynecologic oncology

authors： Tortorella L,Casarin J,Mara KC,Weaver AL,Multinu F,Glaser GE,Cliby WA,Scambia G,Mariani A,Kumar A

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Determining whether carcinomas concurrently involving endometrium and ovary are independent primary tumors (IPTs) or endometrial carcinomas with ovarian metastases (at least stage IIIA endometrial cancers, IIIA-EC) using clinicopathologic criteria is often challenging. Recent genomic studies showed that most ...

journal_title：Gynecologic oncology

authors： Turashvili G,Gómez-Hidalgo NR,Flynn J,Gonen M,Leitao MM Jr,Soslow RA,Murali R

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:To evaluate the effectiveness of bevacizumab with single-agent chemotherapy for platinum-resistant ovarian cancer in a real-world setting. PATIENTS AND METHODS:We enrolled recurrent platinum-resistant ovarian cancer patients from 27 institutions. All had received bevacizumab with single-agent chemotherapy (wee...

journal_title：Gynecologic oncology

authors： Lee JY,Park JY,Park SY,Lee JW,Kim JW,Kim YB,Jeong DH,Lee KB,Kim TH,Lee IH,Choi MC,Kim KH,Kim YM,Lee YJ,Kang S,KGOG Investigators.,Pujade-Lauraine E

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the prevalence and associated prognostic indicators in patients with vulvar carcinoma with and without evidence of perineural invasion (PNI). METHODS:A retrospective review identified 421 patients with invasive vulvar carcinoma evaluated at a single institution between 1993 and 2011. Medical rec...

journal_title：Gynecologic oncology

authors： Salcedo MP,Sood AK,Dos Reis R,Ramalingam P,Chen C,Frumovitz M,Jhingran A,Pitcher B,Ramirez PT,Schmeler KM

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Estimate the prevalence of cardiovascular disease risk factors and endpoints in women with BRCA mutations. METHODS:Women, age 40 and older, with BRCA mutations identified in Kaiser Permanente Northern California completed a questionnaire and underwent a lipid and fasting glucose panel. Bivariable analysis of...

journal_title：Gynecologic oncology

authors： Powell CB,Alabaster A,Armstrong MA,Stoller N,Raine-Bennett T

更新日期：2018-12-01 00:00:00

abstract：:Uterine leiomyosarcoma is the most common type of uterine sarcoma. It is an extremely aggressive malignancy associated with a poor overall prognosis. Women affected may vary in age, but are most often diagnosed in their perimenopausal years. Presenting symptoms may be vague and mimic other benign uterine conditions. P...

journal_title：Gynecologic oncology

authors： Roberts ME,Aynardi JT,Chu CS

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the utility of amiodarone and its derivative dronedarone as novel drug repositioning candidates in EOC and to determine the potential pathways targeted by these drugs. METHODS:Drug-predict bioinformatics platform was used to assess the utility of amiodarone as a novel drug-repurposing candidate i...

journal_title：Gynecologic oncology

authors： Belur Nagaraj A,Joseph P,Kovalenko O,Wang Q,Xu R,DiFeo A

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To compare clinical outcomes of patients diagnosed with low-risk gestational trophoblastic neoplasia (GTN) receiving intramuscular methotrexate 50 mg total dose/day versus 1 mg/kg/day in a 8-day methotrexate/folinic acid (MTX/FA) regimen. METHODS:This retrospective, multicenter study included 176 patients: 9...

journal_title：Gynecologic oncology

authors： Mangili G,Cioffi R,Danese S,Frigerio L,Ferrandina G,Cormio G,Rabaiotti E,Scarfone G,Gadducci A,Bergamini A,Pisano C,Candiani M

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:The present study aimed to evaluate the association between altered methylation and histologically confirmed high grade cervical intraepithelial neoplasia (hgCIN). METHODS:Methylation levels in selected host (CADM1, MAL, DAPK1) and HPV (L1_I, L1_II, L2) genes were measured by pyrosequencing in DNA samples ob...

journal_title：Gynecologic oncology

authors： Fiano V,Trevisan M,Fasanelli F,Grasso C,Marabese F,da Graça Bicalho M,de Carvalho NS,Maestri CA,Merletti F,Sacerdote C,De Marco L,Gillio-Tos A

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Self-collected HPV testing could substantially reduce disparities in cervical cancer screening, with slightly lower sensitivity compared to physician-collected specimens cross-sectionally. We aimed to evaluate the comprehensive long-term performance of self-collected HPV testing prospectively. METHODS:In 199...

journal_title：Gynecologic oncology

authors： Zhang L,Xu XQ,Hu SY,Chen F,Zhang X,Pan QJ,Zhang WH,Feng RM,Dong L,Zhang Q,Ma JF,Sauvaget C,Zhao FH,Qiao YL,Sankaranarayanan R

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Primary objective of this study was to determine prognostic significance of Bohm's histopathological regression score in patients who received neoadjuvant chemotherapy (NACT) for treatment of high grade serous (HGS) tubal & ovarian carcinoma. METHODS:This was a retrospective cohort study of patients who rece...

journal_title：Gynecologic oncology

authors： Rajkumar S,Polson A,Nath R,Lane G,Sayasneh A,Jakes A,Begum S,Mehra G

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to analyze risk factors for septic complications during adjuvant chemotherapy and their impact on survival in patients with advanced epithelial ovarian cancer treated with neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). METHODS:We retrospectively revie...

journal_title：Gynecologic oncology

authors： Son JH,Lee JH,Jung JA,Kong TW,Paek J,Chang SJ,Ryu HS

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of involved-field radiation therapy (IFRT) in patients with locoregionally confined recurrent or persistent epithelial ovarian cancer. METHODS:This study included patients with recurrent epithelial ovarian cancer eligible for IFRT either during diagnosis of the recurrence ...

journal_title：Gynecologic oncology

authors： Chang JS,Kim SW,Kim YJ,Kim JY,Park SY,Kim JH,Jang TK,Kim YB

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:To determine the relationship between chemotherapy dose modification (dose adjustment or treatment delay), overall survival (OS) and progression-free survival (PFS) for women with advanced-stage epithelial ovarian carcinoma (EOC) and primary peritoneal carcinoma (PPC) who receive carboplatin and paclitaxel. ME...

journal_title：Gynecologic oncology

authors： Olawaiye AB,Java JJ,Krivak TC,Friedlander M,Mutch DG,Glaser G,Geller M,O'Malley DM,Wenham RM,Lee RB,Bodurka DC,Herzog TJ,Bookman MA

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:We aimed to evaluate whether carboplatin has a comparable efficacy with cisplatin as part of weekly concurrent chemoradiotherapy for cervical cancer (Car-RT vs. Cis-RT). METHODS:A literature search was conducted and both prospective and retrospective studies that evaluated the efficacy of Car-RT for cervica...

journal_title：Gynecologic oncology

authors： Xue R,Cai X,Xu H,Wu S,Huang H

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the hospital-acquired condition (HAC) following oophorectomy and/or hysterectomy for gynecologic cancer patients based on clinical outcomes and costs. MATERIALS AND METHODS:Data were obtained from the Nationwide Inpatient Sample from 2005 to 2011. Chi-squared and Wilcoxon rank sum two-sample test...

journal_title：Gynecologic oncology

authors： Chan JK,Gardner AB,Mann AK,Kapp DS

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Improvements in surgical technique of pelvic exenteration have mainly occurred in the reconstructive phase of the procedure. Quality of life seems to be improved when performing continent rather than non-continent urinary diversion [1]. Unfortunately, Miami continent urinary pouch is a surgical technique not...

journal_title：Gynecologic oncology

authors： Angeles MA,Martínez-Gómez C,Martinez A,Ferron G

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between molecular subtype, intraperitoneal (IP) disease dissemination patterns, resectability, and overall survival (OS) in advanced high-grade serous ovarian cancer (HGSOC). METHODS:Patients undergoing primary surgery for stage III-IV HGSOC at Mayo Clinic from 1994 to 2011 we...

journal_title：Gynecologic oncology

authors： Torres D,Wang C,Kumar A,Bakkum-Gamez JN,Weaver AL,McGree ME,Konecny GE,Goode EL,Cliby WA

更新日期：2018-08-01 00:00:00

abstract：:Angiogenesis is a proven clinical target for the treatment of advanced epithelial ovarian cancer. Vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) offer patients potential new treatment regimens as they can be given as monotherapy, in combination with poly(ADP-ribose) polymerase (PAR...

journal_title：Gynecologic oncology

authors： Liu J,Nicum S,Reichardt P,Croitoru K,Illek B,Schmidinger M,Rogers C,Whalen C,Jayson GC

更新日期：2018-07-01 00:00:00